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Isotretinoin, the drug that revolutionized acne treatment, is the only cost of taking accutane that can clear acne and produce long-term remissions. Since its introduction in, it continues to be a vital and widely used acne medication worldwide. It is used mainly for severe, recalcitrant nodulocystic acne as well as recalcitrant moderate acne. Abroad, isotretinoin tends to be dispensed more liberally than in the US and with a trend toward lower doses. This article will not cover the well known pharmacology, dosing, and side effects of this medication. Educating patients about isotretinoin and how it differs from other treatments is no easy task.

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