Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. The prevalence of obesity has substantially increased since the s. For some individuals, overeating is primarily driven by hunger a state of nutritional deficit, whereas others overeat in the absence of hunger 1, 2. A better understanding of the neurobiological mechanisms for these two types of feeding behaviors is essential to develop rational precision medicines to more effectively treat the complex etiology of obesity. The brain serotonin 5-hydroxytryptamine, 5-HT system plays critical roles in the regulation of feeding. Brain 5-HT is primarily synthesized by neurons in the dorsal Raphe nucleus DRN in the midbrain, which projects to other midbrain regions and the hypothalamus 3. Hunger decreases 5-HT release from the DRN, while satiation increases it 4, suggesting that dynamic 5-HT bioavailability may participate in the physiological regulation of feeding behavior.

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Diagnosis is based on BMI. Treatment includes lifestyle modification eg, in order adipex 37.5 mg, physical activity, and behavior and, for certain patients, drugs or bariatric weight-loss surgery. See also Obesity in Adolescents. Prevalence is highest among Hispanics Black men in higher income groups are more likely to be obese than those in lower income groups. However, women in higher income groups are less likely to be obese, except for black women.

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